A PGC-1alpha-dependent decrease in mitochondrial oxidative metabolism in muscle of humans with inherited insulin resistance

We used microarrays to assess gene expression profiling of 6 patients with a mutation (Arg1174Gln) in the tyrosine kinase domain of the insulin receptor gene (INSR) and 10 matched healthy controls

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Kristensen JM, Skov V, Petersson SJ, Ørtenblad N, Wojtaszewski JF, Beck-Nielsen H, Højlund K