An RNAi screen unveils a new player in stem cell self-renewal and long-term regeneration

Mouse hair follicles undergo synchronized cycles. Cyclical regeneration and hair growth is fueled by stem cells (SCs). Following hair regeneration, SCs within the bulge and its vicinity (upper ORS which becomes the bulge for the next cycle) briefly self-renew to replenish expended SCs and ensure long-term tissue regeneration.

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Chen T, Heller E, Beronja S, Oshimori N, Stokes N, Fuchs E