Expression data from trisomy 21 and euploid induced pluripotent stem cell hematopoietic progenitors

GSE35561

Homo sapiens

6 Downloadable Samples

Affymetrix Human Gene 1.0 ST Array (hugene10st)

Submitter Supplied Information

Description

We modeled human Trisomy 21 primitive hematopoiesis using induced pluripotent stem cells (iPSCs). Primitive multipotent progenitor populations generated from Trisomy 21 iPSCs showed normal proliferative capacity and megakaryocyte production, enhanced erythropoiesis and reduced myeloid development compared to euploid iPSCs.

PubMed ID

23045704

Publication Title

Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells.

Total Samples

Submitter’s Institution

Pennsylvania State University

Authors

Chou ST, Byrska-Bishop M, Tober JM, Yao Y, Vandorn D, Opalinska JB, Mills JA, Choi JK, Speck NA, Gadue P, Hardison RC, Nemiroff RL, French DL, Weiss MJ

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-35561

No rows found