Mitochondrial 12S hypermethylation in HeLa cells and A1555G cybrids

GSE33780

Homo sapiens

6 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

This dataset investigates the transcriptional effect of mitochondrial 12S rRNA hypermethylation, both by overexpressing the mitochondrial methyltransferase mtTFB1 in HeLa cells and by using A1555G cybrids, where the 12S rRNA is hypermethylated. HeLa cells overexpressing a methyltransferase-deficient mtTFB1 (mtTFB1[G65A]) and wild-type A1555A cybrids were used as controls.

PubMed ID

22341444

Publication Title

Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness.

Total Samples

Submitter’s Institution

Goettingen Universitatsmedizin

Authors

Raimundo N, Song L, Shutt TE, McKay SE, Cotney J, Guan MX, Gilliland TC, Hohuan D, Santos-Sacchi J, Shadel GS

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-33780

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