Expression data of multiple sclerosis patients receiving subcutaneous Interferon-beta-1a therapy [U133 Plus 2.0]

GSE33464

Homo sapiens

59 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

The purpose of this study was to characterize the transcriptional effects induced by subcutaneous IFN-beta-1a treatment (Rebif, 22 g or 44 g three times a week) in patients with relapsing-remitting form of multiple sclerosis (MS). By using Affymetrix DNA microarrays, we obtained genome-wide expression profiles of peripheral blood mononuclear cells from 12 MS patients within the first two years of IFN-beta administration.

PubMed ID

22727118

Publication Title

Elevated type I interferon-like activity in a subset of multiple sclerosis patients: molecular basis and clinical relevance.

Total Samples

Submitter’s Institution

University of Rostock

Authors

Hundeshagen A, Hecker M, Paap BK, Angerstein C, Kandulski O, Fatum C, Hartmann C, Koczan D, Thiesen HJ, Zettl UK

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-33464

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