github link
Accession IconGSE33309

Global gene expression of bovine monocyte-derived macrophages in response to in vitro challenge with Mycobacterium bovis

Organism Icon Bos taurus
Sample Icon 48 Downloadable Samples
Technology Badge Icon Affymetrix Bovine Genome Array (bovine)

Submitter Supplied Information

Description
Background: Mycobacterium bovis, the causative agent of bovine tuberculosis, is a major cause of mortality in global cattle populations. Macrophages are among the first cells types to encounter M. bovis following exposure and the response elicited by these cells is pivotal in determining the outcome of infection. Here, a functional genomics approach was undertaken to investigate global gene expression profiles in bovine monocyte-derived macrophages (MDM) purified from seven age-matched non-related females, in response to in vitro challenge with M. bovis (multiplicity of infection 2:1). Total cellular RNA was extracted from non-challenged control and M. bovis-challenged MDM for all animals at intervals of 2 hours, 6 hours and 24 hours post-challenge and prepared for global gene expression analysis using the Affymetrix GeneChip Bovine Genome Array.
PubMed ID
Total Samples
49
Submitter’s Institution
Alternate Accession IDs

Samples

Show of 0 Total Samples
Filter
Add/Remove
Accession Code
Title
Sex
Age
Specimen part
Time
Processing Information
Additional Metadata
No rows found
Loading...