The role of sepsis in the development of limb muscle weakness in a porcine ICU model

Background : The aim of this study is to improve our understanding of the mechanisms underlying the role of sepsis in the limb muscles of ICU patients with acute quadriplegic myopathy (AQM) by using a unique porcine ICU model, i.e., 5-day longitudinal experiments where animals are sedated, mechanically ventilated and exposed to factor triggering AQM that is endotoxin-induced sepsis.

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Aare S, Radell P, Eriksson LI, Chen YW, Hoffman EP, Larsson L