Host gene expression response to Toxoplasma gondii infection is not different between RHku80 and RHku80rop5 parasites

The normally virulent type-I RH parasite is rendered avirulent when lacking ROP5. The avirulent phenotype is a consequence of interaction with the host innate immune system. We sought to understand if ROP5 alters host gene expression in order to escape host defenses. We saw no gene expression differences between host cells infected with wt (RHku80) or RHku80rop5 parasites. We have included uninfected HFF samples that were harvested in parallel with the infected samples.

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Behnke MS, Fentress SJ, Mashayekhi M, Li LX, Taylor GA, Sibley LD