Epigenome profiling of repressive histone modifications, DNA methylation and gene expression in normal and malignant urothelial cells

To gain a more depth knowledge of repressive epigenetic gene regulation in UCC, we have profiled H3K9m3 and H3K27m3 in normal and malignant urothelial cells. We matched these profiles to those 5-methylcytosine and gene expression. We hypothesized that differences represent pro-carcinogenic events within the urothelium.

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Dudziec E, Gogol-Döring A, Cookson V, Chen W, Catto J