Gene expression in response to short and long term cAMP stimulation in the INS-1 insulinoma cell line

Long term exposure to incretin hormones is known to have salutory effects on beta cell function and viability. While short-term cAMP induction is known to have a signature CREB-CRTC target gene response, the long-term effects of cAMP on beta cell gene expression are less well understood.

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Van de Velde S, Hogan MF, Montminy M