The Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation

Polycomb group (PcG) proteins form multiprotein complexes, called Polycomb repressive complexes (PRCs). PRC2 contains the PcG proteins EZH2, SUZ12, and EED and represses transcription through methylation of lysine (K) 27 of histone H3 (H3). Suz12 is essential for PRC2 activity and its inactivation results in early lethality of mouse embryos.

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Pasini D, Bracken AP, Hansen JB, Capillo M, Helin K