Gene expression profile of preclinical arthritis and its modulation by antigen-induced tolerance

During the course of adjuvant arthritis, maximal changes in gene expression were observed at the incubation phase. A major group of genes affected was related to immune activity. Tolerance induction by mycobacterial heat-shock protein 65 (Bhsp65), the disease-related antigen, caused upregulation of a large number of genes. These included immune activity genes as well as cell proliferation-related genes.

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Yu H, Lu C, Tan MT, Moudgil KD