The role of Raf-1 kinase inhibitor protein in the regulation of pancreatic beta cell proliferation in mice

AIMS/HYPOTHESIS: Manoeuvres aimed at increasing beta cell mass have been proposed as regenerative medicine strategies for diabetes treatment. Raf-1 kinase inhibitor protein 1 (RKIP1) is a common regulatory node of the mitogen-activated protein kinase (MAPK) and nuclear factor B (NF-B) pathways and therefore may be involved in regulation of beta cell homeostasis. The aim of this study was to investigate the involvement of RKIP1 in the control of beta cell mass and function.

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Pardo FN, Altirriba J, Pradas-Juni M, García A, Ahlgren U, Barberà A, Slebe JC, Yáñez AJ, Gomis R, Gasa R