Sox17-transgenic hematopoietic stem cell microarray

GSE30445

Mus musculus

10 Downloadable Samples

Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Submitter Supplied Information

Description

The transcription factor SOX17 is expressed by fetal, but not adult hematoipoietic stem cells (HSCs), and is required for the maintenance of fetal and neonatal, but not adult, HSCs. In the current study we show that ectopic expression of Sox17 in adult HSCs and transiently reconstituting multipotent progenitors was sufficient to confer increased self-renewal potential and the expression of fetal HSC genes including fetal HSC surface markers.

PubMed ID

21828271

Publication Title

Sox17 expression confers self-renewal potential and fetal stem cell characteristics upon adult hematopoietic progenitors.

Total Samples

Submitter’s Institution

University of Michigan

Authors

He S, Kim I, Lim MS, Morrison SJ

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-30445

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