DMSO control and DZNep treated MOLM-14 cells

GSE30315

Homo sapiens

4 Downloadable Samples

Affymetrix Human Gene 1.0 ST Array (hugene10st)

Submitter Supplied Information

Description

We demonstrated that 3-Deazaneplanocin A (DZNep), a histone methyltransferase inhibitor, induce robust apoptosis in AML cells through increased ROS production and ER stress.

PubMed ID

21734239

Publication Title

The histone methyltransferase inhibitor, DZNep, up-regulates TXNIP, increases ROS production, and targets leukemia cells in AML.

Total Samples

Submitter’s Institution

Cancer Science Institute Singapore

Authors

Zhou J, Bi C, Cheong LL, Mahara S, Liu SC, Tay KG, Koh TL, Yu Q, Chng WJ

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-30315

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