Expression data from Tnrc6a (GW182) mutant yolk sac

GW182 (Tnrc6a) is a key component of RISC (miRNA-Induced Silencing Complex) that plays a critical role in miRNA-mediated gene silencing. Here, we show that GW182 is expressed in the yolk sac endoderm, and that gene-trap disruption of GW182 leads to growth arrest of yolk sac endoderm, impaired hematopoiesis and embryonic lethality.

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Jiang Z, Yu N, Kuang P, Chen M, Shao F, Martin G, Chui DH, Cardoso WV, Ai X, Lü J