Function-based discovery of significant transcriptional temporal patterns in insulin-stimulated muscle cells

Background: Insulin's effect on protein synthesis (translation of transcripts) and post-translational modifications, especially those involving reversible modifications such as phosphorylation of various signaling proteins, are extensively studied. On the other hand, insulin's effect on the transcription of genes, especially of transcriptional temporal patterns, is not well investigated in the literature.

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Di Camillo B, Irving BA, Schimke J, Sanavia T, Toffolo G, Cobelli C, Nair KS