Expression comparison between SMC4 and conventional cultures

The undifferentiated state of pluripotent stem cells depends heavily on the culture conditions. We show that a unique combination of small molecules, SMC4, added to culture conditions converts primed pluripotent stem cells to a more nave state. By conducting Affymetix analysis we show of majority of lineage markers are repressed in SMC4 culture.

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Valamehr B, Abujarour R, Robinson M, Le T, Robbins D, Shoemaker D, Flynn P