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Accession IconGSE28585

Dynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging- Related Transcriptional Networks (Illumina)

Organism Icon Mus musculus
Sample Icon 2 Downloadable Samples
Technology Badge IconIllumina MouseRef-8 v2.0 expression beadchip

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Description
Sirtuins (Sirt) are a family of enzymes that modify chromatin and other proteins to affect gene activity. Loss of Sirt6 leads to a progeria-like phenotype in mice, but the target of SIRT6 action has been elusive. Here we show that Sirt6 binds to thousands of gene promoters in a stress-inducible fashion, guided by the stress-responsive transcription factor NF-B.
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