Expression data from TGFbeta-treated control or aPKC silenced A549 cells

Aberrant TGFbeta signalling is a hallmark of epithelial derived tumours. Signalling patterns can depend on the membrane trafficking and internalization of the TGFbeta receptors. Protein kinase C (PKC), particularly the atypical PKC isoforms, alter the trafficking of TGFbeta receptors and can alter TGFbeta induced gene expression.

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Gunaratne A, Chan E, El-Chabib TH, Carter D, Di Guglielmo GM