Comparative analysis of mouse cardiac gene expression: diet, sex, and disease

The perception that soy food products and dietary supplements will have beneficial effects on heart health has led to a massive consumer market. However, we have previously noted that diet has a profound effect on disease progression in a genetic model of hypertrophic cardiomyopathy (HCM). In this model, a soy-based diet negatively impacts cardiac function in male mice.

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Luczak ED, Barthel KK, Stauffer BL, Konhilas JP, Cheung TH, Leinwand LA