Effect of PDE4 inhibition on host gene expression of Mtb-infected mouse lungs.

GSE25313

Mus musculus

47 Downloadable Samples

Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Submitter Supplied Information

Description

Global gene expressions of Mtb-infected mouse lungs were compared between with and without PDE4 inhibitor treatment. A lot of host genes are differentially expressed 21d and 28d post-Mtb infection. PDE4 inhibitor, however, downregulate 10% of genes among those and genes differentially regulated by PDE4 inhibitor are mainly involved immune response.

PubMed ID

21364878

Publication Title

Phosphodiesterase 4 inhibition reduces innate immunity and improves isoniazid clearance of Mycobacterium tuberculosis in the lungs of infected mice.

Total Samples

Submitter’s Institution

University of Medicine and Dentistry of New Jersey

Authors

Koo MS, Manca C, Yang G, O'Brien P, Sung N, Tsenova L, Subbian S, Fallows D, Muller G, Ehrt S, Kaplan G

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-25313

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