Expression data from third instar Drosophila eye discs

Third instar larval eye discs provide an in vivo model for cell cycle exit studies. Posterior to the Second Mitotic Wave proliferation is absent in a wild type eye disc. Inactivating mutations in tumor suppressor-like genes can lead to genome wide changes in gene expression that allow for inappropriate bypass of cell cycle exit signals posterior to the Second Mitotic Wave.

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Nicolay BN, Bayarmagnai B, Islam AB, Lopez-Bigas N, Frolov MV