Expression data of wild-type and dcl1-15 torpedo-staged embryos

Severe loss-of-function alleles of DCL1 are embryonic lethal. Defects in cell division were seen as early as the globular stage in the strong loss-of-function allele dcl1-15. Phenotypic work with dcl1-15 and the null allele dcl1-5 suggested that, in addition to the severe patterning defects, the mutants were maturing earlier than wild-type embryos.

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Willmann MR, Mehalick AJ, Packer RL, Jenik PD