Neonatal beta cells lack the specialized metabolic phenotype of mature beta cells

GSE24790

Rattus norvegicus

4 Downloadable Samples

Affymetrix Rat Genome U34 Array (rgu34a)

Submitter Supplied Information

Description

Fetal and neonatal beta cells have poor glucose-induced insulin secretion and only gain robust glucose responsiveness several weeks after birth. This unresponsiveness may be due to a generalized immaturity of the metabolic pathways normally found in beta cells.

PubMed ID

21240476

Publication Title

Rat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells.

Total Samples

Submitter’s Institution

Joslin Diabetes Center

Authors

Jermendy A, Toschi E, Aye T, Koh A, Aguayo-Mazzucato C, Sharma A, Weir GC, Sgroi D, Bonner-Weir S

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-24790

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