Genomic Collaboration of Estrogen Receptor- and ERK2 in Regulating Gene and Proliferation Programs

The nuclear hormone receptor, estrogen receptor-alpha (ER), and MAP kinases both play key roles in hormone-dependent cancers, yet their interplay and the integration of their signaling inputs remain poorly understood. In these studies, we document that estrogen-occupied ER activates and interacts with ERK2, a downstream effector in the MAPK pathway, resulting in ERK2 and ER colocalization at chromatin binding sites across the genome of breast cancer cells.

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Madak-Erdogan Z, Lupien M, Stossi F, Brown M, Katzenellenbogen BS