Gene expression study identifies important protective pathways utilized by appendicitis and appendectomy for ameliorating colitis

BACKGROUND: Appendicitis followed by appendectomy (AA) at a young age protects against later inflammatory bowel disease (IBD). Using a novel murine appendicitis model we earlier demonstrated that AA proffered significant protection against subsequent experimental colitis.

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Cheluvappa R, Luo AS, Palmer C, Grimm MC