Analysis of cohesin-dependent gene regulation in fission yeast

In addition to its well-know function in chromosome segregation, increasing evidence implicates cohesin in the control of gene expression. It has been previously reported that inactivation of the cohesin loader Mis4 in G1-arrested cells leads to the dissociation of cohesin from chromatin. We exploited this experimental situation to ask whether this loss of cohesin would affect gene expression on a genome-wide scale.

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Dheur S, Saupe SJ, Genier S, Vazquez S, Javerzat JP