An Association Between Gene Expression and Better Survival in Female Mice Following Myocardial Infarction

Following myocardial infarction, the prognosis for females is better than males. Estrogen is thought to be protective, but clinical trials with hormone replacement failed to show protection. Here, we sought to identify novel mechanisms that might explain this sex-based difference. By diverging from the traditional focus on sex hormones, we employed a conceptually novel approach to this question by using a non-biased approach to measure global changes in gene expression following infarction.

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Chen Q, Williams R, Healy CL, Wright CD, Wu SC, O'Connell TD