Loss of Hepatocyte-Nuclear-Factor-1 Impacts on Adult Mouse Intestinal Epithelial Cell Growth and Cell Lineages Differentiation

Although hepatocyte-nuclear-factor-1 (Hnf1) is crucial for pancreas and liver functions, it is believed to play a limited functional role for intestinal epithelial functions. The aim of this study was to assess the consequences of abrogating Hnf1 on the maintenance of adult small intestinal epithelial functions.

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Lussier CR, Brial F, Roy SA, Langlois MJ, Verdu EF, Rivard N, Perreault N, Boudreau F