Temporal and regional regulation of gene expression by calcium-stimulated adenylyl cyclase activity during fear memory

Mice with the two calcium-stmulated adenylyl cyclase isoforms (AC1 and AC8; DKO mice) knocked-out show conditioned fear memory deficits. We assessed gene expression changes at baseline and several time points after conditioned fear learning to assess transcriptional changes at different stages of learning. Transcriptional changes were assessed in the amydgdala and hippocampus of DKO and wild-type mice.

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Wieczorek L, Maas JW Jr, Muglia LM, Vogt SK, Muglia LJ