Expression data from MMP-8 wild type and KO mice with or without arthritis

GSE22971

Mus musculus

12 Downloadable Samples

Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Submitter Supplied Information

Description

Rheumatoid arthritis is an autoimmune disease in which joint inflammation lead to progressive cartilage and bone destruction. Matrix metalloproteinases (MMP) implicated in homeostasis of extracellular matrix (ECM) play a central role in cartilage degradation. The aim of this study was to investigate the role of MMP-8 (collagenase-2) suppression in the K/BxN serum-transfer arthritis model.

PubMed ID

21190566

Publication Title

Matrix metalloproteinase-8 deficiency increases joint inflammation and bone erosion in the K/BxN serum-transfer arthritis model.

Total Samples

Submitter’s Institution

Hospital Clinico Universitario

Authors

García S, Forteza J, López-Otin C, Gómez-Reino JJ, González A, Conde C

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-22971

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