Effect of 52 weeks of chronic exposure to TCDD AND PCB126 on hepatic gene expression

GSE22263

Rattus norvegicus

15 Downloadable Samples

Affymetrix Rat Genome U34 Array (rgu34a)

Submitter Supplied Information

Description

This study investigates the effects of the aryl hydrocarbon receptor (AhR) ligands TCDD and PCB126 on hepatic gene expression in female sprague dawley rats. Rats were treated with toxicological equivalent doses of TCDD (100ng/kg/day) (Toxic equivalence factor (TEF) = 1.0), PCB126 (30ng, 300ng or 1000ng/kg/day) (TEF = 0.1) or a vehicle control of corn oil:acetone (99:1) 5 days a week for 52 weeks.

PubMed ID

20959002

Publication Title

Toxicogenomic analysis of exposure to TCDD, PCB126 and PCB153: identification of genomic biomarkers of exposure to AhR ligands.

Total Samples

Submitter’s Institution

University at Buffalo

Authors

Ovando BJ, Ellison CA, Vezina CM, Olson JR

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-22263

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