Expression Profile of Chicken Primitive Streak (HH4) Tissues

In birds and mammals, all mesoderm cells are generated from the primitive streak. Nascent mesoderm cells contain unique dorso-ventral (D/V) identities depending on their relative ingression position along the streak. Molecular mechanisms controlling this initial phase of mesoderm diversification are not well-understood. Using chick model, we generated high-quality transcriptomic datasets of different streak regions and analyzed their molecular heterogeneity.

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Alev C, Wu Y, Kasukawa T, Jakt LM, Ueda HR, Sheng G