Expression data from human skin exposed to solar-simulated radiation with or without sunscreen

Despite widespread use of sunscreens that minimize erythema by blocking ultraviolet B (UVB) radiation, incidence rates of melanoma continue to rise. In considering this disparity between intervention and disease prevalence, we investigated the in vivo transcriptome of human skin treated with sunscreen and solar-simulated radiation (ssR). A focal skin area of healthy participants was exposed to ssR at 1 minimal erythema dose (MED), 0.1 MED or 100 J/m2 with or without prior application of sunscreen, or to non-UVB-spectrum of ssR (solar-simulated UVA/visible/infrared radiation: ssA). Skin biopsies were analyzed using expression microarrays.

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Tock CL, Turner LR, Altiner A, Batra P, Booher SL, Coelho SG, Warner JA, Therrien JP, Turner ML, Miller SA, Beer JZ, Kraemer KH, Udey MC, Vogel JC, Terunuma A