Gene expression profiles of HCT116 colorectal carcinoma cells treated with HDAC inhibitors

GSE22061

Homo sapiens

8 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

Histone deacetylases (HDACs) regulate gene expression. Inhibition of class I HDACs has been shown to inhibit cancer cell growth. Largazole, a new potent HDAC inhibitor, shows strong antitumor activity, presumably by modulating transcription of cancer relevant genes.

PubMed ID

20739454

Publication Title

Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor.

Total Samples

Submitter’s Institution

University of Florida

Authors

Liu Y, Salvador LA, Byeon S, Ying Y, Kwan JC, Law BK, Hong J, Luesch H

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-22061

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