Expression data from insulin-treated human primary fibroblasts and effects of U0126 on insulin-induced gene expression

We carried out a high throughput analysis of insulin-induced kinase signaling pathways in primary fibroblasts from 35 unrelated individuals. We found that extensive individual variation exists in induction of various signaling pathways. ERK signaling displayed the greatest variation, which led to extensive variation in expression of downstream target genes.

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Wang IX, Ramrattan G, Cheung VG