Effect of IL-1b treatment on cultured rat aortic smooth muscle cells

GSE21403

Rattus norvegicus

4 Downloadable Samples

Affymetrix Rat Genome 230 2.0 Array (rat2302)

Submitter Supplied Information

Description

IL-1 plays an important role in atherosclerosis, and alters expression of a number of genes involved in atherosclerotic plaque development and progression. Smooth muscle cells play important roles in atherosclerotic plaque formation and stability, so this study was undertaken to determine the global effects of IL-1b on gene expression in smooth muscle cells in vitro.

PubMed ID

22201681

Publication Title

Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice.

Total Samples

Submitter’s Institution

University of Virginia

Authors

Alexander MR, Moehle CW, Johnson JL, Yang Z, Lee JK, Jackson CL, Owens GK

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-21403

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