Multi-level Support Vector Regression analysis to identify condition-specific regulatory networks

The identification of gene regulatory modules is an important yet challenging problem in computational biology. While many computational methods have been proposed to identify regulatory modules, their initial success is largely compromised by a high rate of false positives, especially when applied to human cancer studies. New strategies are needed for reliable regulatory module identification.

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Chen L, Xuan J, Riggins RB, Wang Y, Hoffman EP, Clarke R