Expression data from white and brown adipose tissue (WAT and BAT) of per2-/- and control mice

GSE20165

Mus musculus

12 Downloadable Samples

Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Submitter Supplied Information

Description

We found that the circadian protein PER2 interacts with the nuclear receptor PPARgamma to repress its activity. PPARgamma is a master regulator of adipogenesis and lipid metabolism and is very abundant in adipose tissue. We used microarrays to detail the global program of gene expression in adipose tissue lacking the per2 gene. This analysis identified several PPARgamma target genes up-regulated in adipose tissue from per2-/- mice.

PubMed ID

21035761

Publication Title

PER2 controls lipid metabolism by direct regulation of PPARγ.

Total Samples

Submitter’s Institution

university of california, irvine

Authors

Grimaldi B, Bellet MM, Katada S, Astarita G, Hirayama J, Amin RH, Granneman JG, Piomelli D, Leff T, Sassone-Corsi P

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-20165

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