Comparative transcriptome analysis of yeast expressing the fungal desaturases

GSE20155

Saccharomyces cerevisiae

9 Downloadable Samples

Affymetrix Yeast Genome 2.0 Array (yeast2)

Submitter Supplied Information

Description

To study how the presence of PUFAs influences central cellular processes, and in order to perform lipidome, transcriptome and molecular studies we decided to use yeast as a model organism. We therefore co-expressed 12-desaturase and 6- desaturase genes from Mucor rouxii in S. cerevisiae with the objective to obtain a yeast strain that contains PUFAs, especially linoleic acid (LA, C18:29,12) and -linolenic acid (GLA, C18:36,9,12), in its membranes.

PubMed ID

21184438

Publication Title

Heterologous production of polyunsaturated fatty acids in Saccharomyces cerevisiae causes a global transcriptional response resulting in reduced proteasomal activity and increased oxidative stress.

Total Samples

Submitter’s Institution

Chalmers University of Technology

Authors

Ruenwai R, Neiss A, Laoteng K, Vongsangnak W, Dalfard AB, Cheevadhanarak S, Petranovic D, Nielsen J

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-20155

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