Molecular basis for vulnerability to mitochondrial and oxidative stress in an insulinoma cell line

BACKGROUND: Many age-associated disorders (including diabetes, cancer, and neurodegenerative diseases) are linked to mitochondrial dysfunction, which leads to impaired cellular bioenergetics and increased oxidative stress. However, it is not known what genetic and molecular pathways underlie differential vulnerability to mitochondrial dysfunction observed among different cell types.

12

Chandiramani N, Wang X, Margeta M