Time series gene expression data from adult rat tail MNs following spinal cord transection

Spinal cord injury leads to impaired motor and sensory functions. After spinal cord injury there is a an initial phase of hypo-reflexia followed by a developing hyper-reflexia, often termed spasticity. Previous studies have suggested a relationship between the reappearence of plateau potentials in motor neurons and the development of spasticity after spinalizaion. To understand the moleclar mechanism behind this pheneomona we examined the transcriptional response of the motor neurons after spinal cord injury as it progress over time.

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Ryge J, Winther O, Wienecke J, Sandelin A, Westerdahl AC, Hultborn H, Kiehn O