Expression data from TKI258 treated 4T1 cells

GSE19220

Mus musculus

6 Downloadable Samples

Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Submitter Supplied Information

Description

4T1 mouse mammary carcinoma cells have an autocrine FGFR active loop leading to constitutive activation of downstream signaling pathways. We found that FGFR inhibitors have a strong effect on the proliferation and survival of these cells.

PubMed ID

20460524

Publication Title

Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis.

Total Samples

Submitter’s Institution

FMI

Authors

Dey JH, Bianchi F, Voshol J, Bonenfant D, Oakeley EJ, Hynes NE

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-19220

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