Differentially expressed mRNA transcripts in the placenta delivered by preterm versus term spontaneous labour

We hypothesized that preterm spontaneous labor involves aberrant changes in mRNA expression in the placenta. To test this hypothesis, we interrogated the mRNA levels of >50,000 genes and transcript variants using gene expression microarray (Human Genome U133 Plus 2.0 Array, Affymetrix) on 5 placentas collected from preterm spontaneous delivery (<34 weeks of gestation) and another 5 placentas collected from term spontaneous delivery (38-39 weeks).

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Chim SS, Lee WS, Ting YH, Chan OK, Lee SW, Leung TY