Transcriptional Signature and Memory Retention of Human-induced Pluripotent Stem Cells

Transient expression of two factors, or from Oct4 alone, resulted in efficient generation of human iPSCs. The reprogramming strategy described revealed a potential transcriptional signature for human iPSCs yet retaining the gene expression of donor cells in human reprogrammed cells free of viral and transgene interference.

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Marchetto MC, Yeo GW, Kainohana O, Marsala M, Gage FH, Muotri AR