Regulatory T cell-mediated resolution of lung injury: Identification of potential target genes via expression profiling

We examined early and late gene expression changes using the IT LPS model of Acute Lung Injury (ALI). In this model, injury peaks at day 4 and is almost completely resolved by day 10 in wild type (WT) C57BL/6 mice. In contrast to the pattern in WT mice, lymphocyte-deficient Rag-1 -/- mice exhibit strikingly delayed resolution despite similar initial injury.

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Aggarwal NR, D'Alessio FR, Tsushima K, Sidhaye VK, Cheadle C, Grigoryev DN, Barnes KC, King LS