Gene Expression upon Doxorubicin Treatments

Murine C26 tumor xenografts displayed different responses to the treatments of PBS, Doxorubicin (Dox), and chimeric polypeptide (CP)-Dox conjugates. We used microarrays to globally study gene expression underlying these different responses and identified distinct classes of up-regulated or down-regulated genes upon treatment.

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MacKay JA, Chen M, McDaniel JR, Liu W, Simnick AJ, Chilkoti A