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Accession IconGSE16990

FOXP3-mediated inhibition of a global gene regulator is required for maintaining Treg cell commitment

Organism Icon Homo sapiens
Sample Icon 12 Downloadable Samples
Technology Badge IconSentrix Human-6 Expression BeadChip

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Description
Regulatory T (Treg) cells are characterized by the forkhead transcription factor FOXP3. Mutations in FOXP3 cause autoimmunity in mice and humans. Here, Treg cells as well as conventional T cells were isolated from B-CLL patients and analyzed by global gene expression analysis in order to identify biological differences in Treg cells of CLL patients.
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