The effect of cardiac troponin T2 knockdown on gene expression in zebrafish embryos

GSE16740

Danio rerio

18 Downloadable Samples

Affymetrix Zebrafish Genome Array (zebrafish)

Submitter Supplied Information

Description

We examined the transcriptional effect of preventing cardiac contraction in zebrafish embryos which can be deprived of circulation without experiencing hypoxia since the fish obtain sufficient oxygen via diffusion. Morpholino antisense knockdown of cardiac troponin T2 (tnnt2) prevented cardiac contraction without affecting vascular development. We concluded that absence of hemodynamic force induces endothelial CXCR4a up-regulation and promotes recovery of blood flow.

PubMed ID

19509081

Publication Title

Microarray profiling reveals CXCR4a is downregulated by blood flow in vivo and mediates collateral formation in zebrafish embryos.

Total Samples

Submitter’s Institution

University of Sheffield

Authors

Packham IM, Gray C, Heath PR, Hellewell PG, Ingham PW, Crossman DC, Milo M, Chico TJ

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-16740

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